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The Gleason score is a measure of thelevel of differentiation of the histology.
Over the past decades, its structure, basic behavior and theanalytical techniques-assisted determination in various matrices have been studied. Hence inflammatory-mediated chlorination of pyrimidine (cytosine) residuesin DNA may account for several DNA alterations observed in human tumors .A significant imbalance between ROS/RNS production and antioxidant defense can explainall findings associating with tumor growth and a state of high oxidative stress .
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Copyright 1991 by the American Speech-Language-HearingAssociation.