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The differences between initiation ofcardiac and skeletalmuscle contractions—the longer lasting membrane depolariza-tion and activation ofvoltage-sensitive Ca2+channels in thewalloftheT tubule—account for an approximately200-milliseconddelay from the start ofdepolarization in a cardiac muscle twitch(see Fig. A second nucleus(arrow), which appears intimately related to one of the adipose cells, may actually belong to a fibroblast; it is difficult to tell with assurance.Because of the large size of adipose cells, the nucleus is infrequently observed in a given cell. An effective enzyme replace-ment therapy was developed for type I or non-neuronopathic Gaucher disease usinghighly puri?ed placenta-derived glucocerebrosidase. Biotransformationis also decreased because of the decrease in liver mass,blood flow, activity of cytochrome P450 enzymes, andphase II conjugation enzymes.

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